Structure of PDB 3v3b Chain A

Receptor sequence
>3v3bA (length=87) Species: 9606 (Homo sapiens) [Search protein sequence]
QETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQH
IVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB3v3b Structure of the stapled p53 peptide bound to Mdm2.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 G58 I61 M62 Y67 Q72 H73 V93 Y100 L31 G35 I38 M39 Y44 Q49 H50 V70 Y77
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3v3b, PDBe:3v3b, PDBj:3v3b
PDBsum3v3b
PubMed22148351
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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