Structure of PDB 3v2w Chain A

Receptor sequence
>3v2wA (length=442) Species: 9606,10665 [Search protein sequence]
SDYVNYDIIVRHYNYTGKLNISALTSVVFILICCFIILENIFVLLTIWKT
KKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGS
MFVALSASVFSLLAIAIERYITMLKNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRT
RNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAI
GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALI
NMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVI
TTFRTGTWDAYASRSSENVALLKTVIIVLSVFIACWAPLFILLLLDVGCK
VKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRI
3D structure
PDB3v2w Crystal structure of a lipid G protein-coupled receptor.
ChainA
Resolution3.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E211 D220
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ML5 A Y29 K34 N101 E121 M124 F125 L128 L276 L297 Y13 K18 N78 E98 M101 F102 L105 L393 L414 PDBbind-CN: -logKd/Ki=7.11,Ki=77nM
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Cellular Component
External links
PDB RCSB:3v2w, PDBe:3v2w, PDBj:3v2w
PDBsum3v2w
PubMed22344443
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P21453|S1PR1_HUMAN Sphingosine 1-phosphate receptor 1 (Gene Name=S1PR1)

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