Structure of PDB 3v1r Chain A

Receptor sequence
>3v1rA (length=165) Species: 356663 (Xenotropic MuLV-related virus VP35) [Search protein sequence]
HGTRPDLTDQPIPDADYTWYTDGSSFLQEGQRRAGAAVTTETEVIWARAL
PAGTSAQRAELIALTQALKMAEGKKLNVYTDSRYAFATAHVHGEIYRRRG
LLTSEGREIKNKNEILALLKALFLPKRLSIIHCPGHQKGNSAEARGNRMA
DQAAREAAMKAVLET
3D structure
PDB3v1r Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D524 E562 D583 D22 E60 D81
BS02 MN A D524 H638 D653 R657 D22 H136 D151 R155
BS03 JTH A D524 E562 H638 R657 D22 E60 H136 R155 PDBbind-CN: -logKd/Ki=7.68,IC50=21nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

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Molecular Function
External links
PDB RCSB:3v1r, PDBe:3v1r, PDBj:3v1r
PDBsum3v1r
PubMed22366278
UniProtQ2F7J3|POL_XMRV3 Gag-Pol polyprotein (Gene Name=gag-pol)

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