Structure of PDB 3uza Chain A

Receptor sequence
>3uzaA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADILVG
VLAIPFAITISTGFCAACHGCLFIACFVLVLAQSSIFSLLAIAIDRYIAI
AIPLRYNGLVTGTRAAGIIAICWVLSFAIGLTPMLGWNNCGQPGCGEGQV
ACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFAAARRQLKQMESQ
PLPGERARSTLQKEVHAAKSAAIIAGLFALCWLPLHIINCFTFFCPDCSH
APLWLMYLAIVLAHTNSVVNPFIYAYRIREFRQTFRKIIRS
3D structure
PDB3uza Discovery of 1,2,4-Triazine Derivatives as Adenosine A(2A) Antagonists using Structure Based Drug Design
ChainA
Resolution3.273 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T4G A F168 M177 L249 H250 N253 I274 F154 M163 L235 H236 N239 I260 PDBbind-CN: -logKd/Ki=8.94,Kd=1.16nM
BindingDB: Ki=7.76nM
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3uza, PDBe:3uza, PDBj:3uza
PDBsum3uza
PubMed22220592
UniProtP29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

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