Structure of PDB 3uyt Chain A

Receptor sequence
>3uytA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKPQLHIESKIYK
MMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLL
LADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYR
DARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFN
LGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRS
LRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB3uyt Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D121 K123
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0CK A I15 I23 A36 M80 M82 L85 L135 I148 I11 I19 A32 M73 M75 L78 L128 I141 PDBbind-CN: -logKd/Ki=7.85,IC50~14nM
BindingDB: IC50=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3uyt, PDBe:3uyt, PDBj:3uyt
PDBsum3uyt
PubMed22168824
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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