Structure of PDB 3uy4 Chain A

Receptor sequence
>3uy4A (length=283) Species: 192222 (Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819) [Search protein sequence]
AMQVITSVKEAKQIVKDWKSHQLSIGYVPTMGFLHDGHLSLVKHAKTQDK
VIVSIFVNPMQFGPNEDFSSYPRDLERDIKMCQDNGVDMVFIPDATQMYL
KNFSTYVDMNTITDKLCGAKRPGHFRGVCTVLTKFFNILNPDIVYMGQKD
AQQCVVVRHMVDDLNFDLKIQICPIIREEDGLAKSSRNVYLSKEERKASL
AISQSIFLAEKLVREGEKNTSKIIQAMKDILEKEKLIKIDYIELVDFNTM
ENIENITDNVLGAVAAFVGKTRLIDNFLVQGLK
3D structure
PDB3uy4 Crystal Structure of Pantoate--Beta-Alanine Ligase from Campylobacter jejuni complexed with AMP and vitamin B5
ChainA
Resolution1.851 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M30 H34 H37 R76 D77 M80 K148 S184 S185 R186
Catalytic site (residue number reindexed from 1) M31 H35 H38 R77 D78 M81 K149 S185 S186 R187
Enzyme Commision number 6.3.2.1: pantoate--beta-alanine ligase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A P28 M30 H37 L40 M145 G146 D149 I174 I175 K183 P29 M31 H38 L41 M146 G147 D150 I175 I176 K184
BS02 PAU A T29 M30 Q60 V130 D149 Q152 R186 T30 M31 Q61 V131 D150 Q153 R187
Gene Ontology
Molecular Function
GO:0004592 pantoate-beta-alanine ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0015940 pantothenate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3uy4, PDBe:3uy4, PDBj:3uy4
PDBsum3uy4
PubMed
UniProtQ9PIK2|PANC_CAMJE Pantothenate synthetase (Gene Name=panC)

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