Structure of PDB 3uw5 Chain A

Receptor sequence
>3uw5A (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFC
YGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIH
3D structure
PDB3uw5 Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152).
ChainA
Resolution1.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G130 L131 Q132 S133 W134 D138 E143 W147 G53 L54 Q55 S56 W57 D61 E66 W70
BS02 peptide A V122 R123 G130 L131 Q132 V45 R46 G53 L54 Q55
BS03 ZN A C124 C127 H144 C151 C47 C50 H67 C74
External links
PDB RCSB:3uw5, PDBe:3uw5, PDBj:3uw5
PDBsum3uw5
PubMed22413863
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP);
Q96CA5|BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (Gene Name=BIRC7)

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