Structure of PDB 3uvu Chain A

Receptor sequence

>3uvuA (length=425) Species: 10090 (Mus musculus) [Search protein sequence]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYF

3D structure

PDB

3uvu Structural basis of nuclear import of flap endonuclease 1 (FEN1).

Chain

Resolution

2.38 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1)	T80 A92 N290 R295 Q296
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 D270 W273 Y277 G281 N283 T311 R315 V321 T322 N350 W357 N361 A364 E396 W399	W71 N75 S78 G79 T84 Q110 W113 N117 D121 W160 R167 D199 W202 Y206 G210 N212 T240 R244 V250 T251 N279 W286 N290 A293 E325 W328

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3uvu, PDBe:3uvu, PDBj:3uvu
PDBsum	3uvu
PubMed	22751659
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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