Structure of PDB 3uva Chain A

Receptor sequence

>3uvaA (length=402) Species: 86665 (Halalkalibacterium halodurans)

KSQFERAKIEYGQWGIDVEEALERLKQVPISIHCFQGDDVGGFELSDYPG
KATTPEELRMDLEKALSLIPGKHRVNLHAIYAETDGKVVERDQLEPRHFE
KWVRWAKRHGLGLDFNPTLFSHEKAKDGLTLAHPDQAIRQFWIDHCIASR
KIGEYFGKELETPCLTNIWIPDGYKDTPSDRLTPRKRLKESLDQIFAAEI
NEAYNLDAVESKLFGIGSESYVVGSHEFYLSYALKNDKLCLLDTGHYHPT
ETVSNKISAMLLFHDKLALHVSRPVRWDSDHVVTFDDELREIALEIVRND
ALDRVLIGLDFFDASINRIAAWTIGTRNVIKALLFAMLIPHKQLKEWQET
GDYTRRLAVLEEFKTYPLGAIWNEYCERMNVPIKEEWLKEIAIYEKEVLL
QR

3D structure

• PDB: 3uva Structure-based studies on the metal binding of two-metal-dependent sugar isomerases.
• Chain: A
• Resolution: 2.69 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): W184 E225 K227 D258 H261 H285 D293 D295 D325
• Catalytic site (residue number reindexed from 1): W169 E210 K212 D243 H246 H270 D278 D280 D310
• Enzyme Commision number: 5.3.1.14: L-rhamnose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	E225 D258 H285 D325	E210 D243 H270 D310
BS02	MN	A	H261 D293	H246 D278

Gene Ontology

Molecular Function

• GO:0008740 L-rhamnose isomerase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019299 rhamnose metabolic process
• GO:0019301 rhamnose catabolic process
• GO:0019324 L-lyxose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3uva, PDBe:3uva, PDBj:3uva
• PDBsum: 3uva
• PubMed: 24925069
• UniProt: Q9KCL9|RHAA_HALH5 L-rhamnose isomerase (Gene Name=rhaA)