Structure of PDB 3usp Chain A

Receptor sequence

>3uspA (length=503) Species: 63363 (Aquifex aeolicus) [Search protein sequence]

REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
AIYYVYIESWTLGFAIKFLVGLVPEPPPTDPDSILRPFKEFLYSYIGVPK
GDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILA
VFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLS
LGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFF
GVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSS
IAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFW
AGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYIT
PAFLAVLLVVWAREYETHWTVWITRFYIIGLFLFLTFLVFLAERRRNHES
AGT

3D structure

PDB

3usp Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NA	A	G20 V23 G24 A351 T354 S355	G16 V19 G20 A345 T348 S349
BS02	NA	A	A22 V23 N27 T254 N286	A18 V19 N23 T248 N280
BS03	LEU	A	A22 G24 G26 F253 T254 S256 F259	A18 G20 G22 F247 T248 S250 F253
BS04	05L	A	K163 H391 L392 F395	K157 H385 L386 F389
BS05	05L	A	E159 I161	E153 I155
BS06	05L	A	P164 Y169 H391 F395	P158 Y163 H385 F389
BS07	05L	A	K121 L126 F167	K117 L122 F161
BS08	05L	A	P445 Y448	P439 Y442
BS09	05L	A	L400 D401 D404	L394 D395 D398

Gene Ontology

	Biological Process
GO:0035725	sodium ion transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3usp, PDBe:3usp, PDBj:3usp
PDBsum	3usp
PubMed	22245965
UniProt	O67854

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