Structure of PDB 3usn Chain A

Receptor sequence
>3usnA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF
SRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDD
DEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRF
RLSQDDINGIQSLYGPPP
3D structure
PDB3usn Solution structures of stromelysin complexed to thiadiazole inhibitors.
ChainA
ResolutionN/A
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H119 E120 H123 H129
Catalytic site (residue number reindexed from 1) H119 E120 H123 H129
Enzyme Commision number 3.4.24.17: stromelysin 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H119 H123 H129 H119 H123 H129
BS02 ZN A H69 D71 H84 H97 H69 D71 H84 H97
BS03 CA A D76 G77 G79 V81 D99 D101 E102 D76 G77 G79 V81 D99 D101 E102
BS04 CA A D59 G91 I92 N93 G94 D95 D59 G91 I92 N93 G94 D95
BS05 CA A D25 D100 D101 E102 D25 D100 D101 E102
BS06 ATT A F4 A83 A85 A87 E120 H123 F4 A83 A85 A87 E120 H123 PDBbind-CN: -logKd/Ki=6.15,Ki=710nM
BindingDB: Ki=710nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Cellular Component
External links
PDB RCSB:3usn, PDBe:3usn, PDBj:3usn
PDBsum3usn
PubMed9827994
UniProtP08254|MMP3_HUMAN Stromelysin-1 (Gene Name=MMP3)

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