Structure of PDB 3ur9 Chain A

Receptor sequence
>3ur9A (length=164) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HMAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIA
IHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLA
VRMGAIASMRIQGRLVHGQSGMLLGTIPGDCGAPYVHKRGNDWVVCGVHA
AATKSNTVVCAVQA
3D structure
PDB3ur9 Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K36 A H30 Q110 T134 C139 H157 A158 A159 A160 H32 Q112 T126 C131 H149 A150 A151 A152 PDBbind-CN: -logKd/Ki=6.31,IC50=0.49uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ur9, PDBe:3ur9, PDBj:3ur9
PDBsum3ur9
PubMed22915796
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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