Structure of PDB 3upy Chain A

Receptor sequence
>3upyA (length=436) Species: 359391 (Brucella abortus 2308) [Search protein sequence]
TTNVALVGLARDLAARAETGKPIRIGLIGAGEMGTDIVTQVARMQGIEVG
ALSARRLPNTFKAIRTAYGDEENAREATTESAMTRAIEAGKIAVTDDNDL
ILSNPLIDVIIDATGIPEVGAETGIAAIRNGKHLVMMNVEADVTIGPYLK
AQADKQGVIYSLGAGDEPSSCMELIEFVSALGYEVVSAGKGKNNPLNFDA
TPDDYRQEADRRNMNVRLLVEFIDGSKTMVEMAAIANATGLVPDIAGMHG
PRASIDQLSHTLIPQAEGGVLSKSGVVDYSIGKGVSPGVFVVAKMDHPRL
NERLEDLKIGKGPYFTFHRPYHLTSLEVPLTVARVVLHGKTDMVPLPKPV
AEVCAVAKKDMQPGEHLDAIGQYCYRSWIMTVPEARAAKAIPCGLLQNGT
VIAPIKKGELITYANAAPQPGSRIAELRALQDAMLG
3D structure
PDB3upy Crystal structure of Brucella abortus deoxyxylulose-5-phosphate reductoisomerase-like (DRL) enzyme involved in isoprenoid biosynthesis.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D167 E168 E232 D166 E167 E231
BS02 FOM A E168 K191 K193 F223 E232 H323 E167 K190 K192 F222 E231 H322 MOAD: ic50=2.39uM
PDBbind-CN: -logKd/Ki=5.62,IC50=2.39uM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050661 NADP binding

View graph for
Molecular Function
External links
PDB RCSB:3upy, PDBe:3upy, PDBj:3upy
PDBsum3upy
PubMed22442144
UniProtQ2YIM3

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