Structure of PDB 3upo Chain A

Receptor sequence
>3upoA (length=442) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
EYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYS
STALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAG
WDAMQQGCYGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQ
AWQRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQLTAA
PTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGAD
ALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTP
LANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVRYQQRRAVSPQVA
AKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAF
APAQAPKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQ
3D structure
PDB3upo The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNM A S222 Y261 S281 N283 Q339 T425 G426 T427 E429 S176 Y215 S235 N237 Q293 T379 G380 T381 E383
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0016787 hydrolase activity
GO:0071972 peptidoglycan L,D-transpeptidase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3upo, PDBe:3upo, PDBj:3upo
PDBsum3upo
PubMed22365933
UniProtP9WKD1|PBPA_MYCTU Peptidoglycan D,D-transpeptidase PbpA (Gene Name=pbpA)

[Back to BioLiP]