Structure of PDB 3ule Chain A

Receptor sequence
>3uleA (length=400) Species: 9913 (Bos taurus) [Search protein sequence]
AGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKEVMKGVDDLDFFI
GDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLL
TEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERT
LTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDRE
VGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAI
SKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVR
RPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSKPKPIDVQ
VITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGV
3D structure
PDB3ule Structure of Bos taurus Arp2/3 complex with bound inhibitor CK-869 and ATP
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G13 T14 Y16 K18 G171 D172 G197 K225 K228 E229 G324 M327 F328 R374 G12 T13 Y15 K17 G159 D160 G185 K213 K216 E217 G312 M315 F316 R358
BS02 C69 A E84 W86 M89 M93 T113 N118 T126 E72 W74 M77 M81 T101 N106 T114
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0030030 cell projection organization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060271 cilium assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0035861 site of double-strand break
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ule, PDBe:3ule, PDBj:3ule
PDBsum3ule
PubMed
UniProtP61157|ARP3_BOVIN Actin-related protein 3 (Gene Name=ACTR3)

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