Structure of PDB 3ukh Chain A

Receptor sequence

>3ukhA (length=504) Species: 746128 (Aspergillus fumigatus)

THPDISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDV
TPEGFLYDVGGHVIFSHYKYFDDCLDEALPKEDDWYTHQRISYVRCQGQW
VPYPFQNNISMLPKEEQVKCIDGMIDAALEARVANTKPKTFDEWIVRMMG
TGIADLFMRPYNFKVWAVPTTKMQCAWLGERVAAPNLKAVTTNVILGKTA
TFRFPARGGTGGIWIAVANTLPKEKTRFGEKGKVTKVNANNKTVTLQDGT
TIGYKKLVSTMAVDFLAEAMNDQELVGLTKQLFYSSTHVIGVGVRGSRPE
RIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPEASKKLPTMQLADGSRPQ
STEAKEGPYWSIMLEVSESSMKPVNQETILADCIQGLVNTEMLKPTDEIV
STYHRRFDHGYPTPTLEREGALTQILPKLQDKDIWSRGRFGSWRYEVGNQ
DHSFMLGVEAVDNIVNGAVELTLNYPDFVNGRQNTERRLVDGAQVFAKSK
AQLE

3D structure

• PDB: 3ukh Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G14 G16 P17 T18 D38 S39 G45 L46 G61 G62 V242 M269 T295 R327 Y419 G446 R447 G456 N457 Q458 S461	G13 G15 P16 T17 D37 S38 G44 L45 G60 G61 V234 M261 T287 R319 Y411 G438 R439 G448 N449 Q450 S453
BS02	GDU	A	I65 Y104 F158 M159 Y162 N163 W315 Y317 R327 Y419 Y453 N457	I64 Y103 F157 M158 Y161 N162 W307 Y309 R319 Y411 Y445 N449

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008767 UDP-galactopyranose mutase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0071555 cell wall organization

External links

• PDB: RCSB:3ukh, PDBe:3ukh, PDBj:3ukh
• PDBsum: 3ukh
• PubMed: 22334662
• UniProt: Q4W1X2|GLFA_ASPFM UDP-galactopyranose mutase (Gene Name=glfA)