Structure of PDB 3ujd Chain A

Receptor sequence
>3ujdA (length=257) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
DKTFLENNQFTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKV
LDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEAN
DILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITD
YCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDY
WNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWG
YFKATKN
3D structure
PDB3ujd Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.103: phosphoethanolamine N-methyltransferase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 PC A Y27 I36 D128 Y160 Y175 R179 Y181 K247 Y18 I27 D119 Y151 Y166 R170 Y172 K238 MOAD: Kd=20.2uM
PDBbind-CN: -logKd/Ki=4.69,Kd=20.2uM
Gene Ontology
Molecular Function
GO:0000234 phosphoethanolamine N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0009058 biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:3ujd, PDBe:3ujd, PDBj:3ujd
PDBsum3ujd
PubMed22117061
UniProtQ8IDQ9|PMT_PLAF7 Phosphoethanolamine N-methyltransferase (Gene Name=PMT)

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