Structure of PDB 3ujb Chain A

Receptor sequence
>3ujbA (length=256) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
KTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVL
DIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEAND
ILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDY
CATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYW
NQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGY
FKATKN
3D structure
PDB3ujb Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.
ChainA
Resolution1.521 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.103: phosphoethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OPE A Q18 Y19 Y27 Y160 Y175 R179 Y181 K247 Q8 Y9 Y17 Y150 Y165 R169 Y171 K237
BS02 SAH A Y19 I36 S37 G63 D85 I86 I111 R127 H132 Y9 I26 S27 G53 D75 I76 I101 R117 H122 PDBbind-CN: -logKd/Ki=5.10,Kd=7.9uM
Gene Ontology
Molecular Function
GO:0000234 phosphoethanolamine N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0009058 biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ujb, PDBe:3ujb, PDBj:3ujb
PDBsum3ujb
PubMed22117061
UniProtQ8IDQ9|PMT_PLAF7 Phosphoethanolamine N-methyltransferase (Gene Name=PMT)

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