Structure of PDB 3uib Chain A

Receptor sequence
>3uibA (length=309) Species: 5664 (Leishmania major) [Search protein sequence]
AAMRDLIAELVQRYGAVCAGVDSEGIPVAIKRVFNTNILSDSFLCKRVLR
EIRLLNHFHHPNILGLRDILYLVTELMRTDLAQVIHDQRIVISPQHIQYF
MYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLYVTHRWYRA
PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVG
TPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKML
EFNPQRRISTEQALRHPYFESLFDPLDLTEGLSERFHFDESVTDVYDMHK
IFTAEVERF
3D structure
PDB3uib The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms.
ChainA
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D158 H160 N163 D176 H195
Catalytic site (residue number reindexed from 1) D120 H122 N125 D138 H145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SB2 A A49 T112 M115 H160 L165 C175 D176 A29 T74 M77 H122 L127 C137 D138 PDBbind-CN: -logKd/Ki=6.80,Kd=0.16uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3uib, PDBe:3uib, PDBj:3uib
PDBsum3uib
PubMed22884419
UniProtQ4QHJ8

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