Structure of PDB 3ugj Chain A

Receptor sequence

>3ugjA (length=1284) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium)

GLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFAD
LNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKAT
DIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSS
LTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQE
AFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIK
NTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMK
VETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRI
PGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTY
EEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGP
AMNIGLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLS
NAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQ
LPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKT
PKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGDRT
VTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFA
ASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKA
VGEELCPQLGLTIPVGKDSMSMKTRWQEGQREMTSPLSLVISAFARVEDV
RHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVA
QLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAA
LGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAG
DRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKAN
DTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFH
RAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSIL
FNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVRNH
SDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAA
LESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHP
ERVFRTVANSWHPENWGEDSPWMRIFRNARKQLG

3D structure

• PDB: 3ugj Formylglycinamide ribonucleotide amidotransferase from Salmonella typhimurium: role of ATP complexation and the glutaminase domain in catalytic coupling
• Chain: A
• Resolution: 1.78 Å

Enzymatic activity

• Enzyme Commision number: 6.3.5.3: phosphoribosylformylglycinamidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	A	T386 G387 Y388 K649 L652 Q668 P676 A678 N722	T394 G395 Y396 K640 L643 Q659 P667 A669 N713
BS02	MG	A	D679 N722 D884	D670 N713 D873

Gene Ontology

Molecular Function

• GO:0004642 phosphoribosylformylglycinamidine synthase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0006541 glutamine metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3ugj, PDBe:3ugj, PDBj:3ugj
• PDBsum: 3ugj
• PubMed: 22683785
• UniProt: P74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)