Structure of PDB 3ufa Chain A

Receptor sequence
>3ufaA (length=199) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]
EKNVKEITDATKEPYNSVVAFVGGTGVVVGKNTIVTNKHIAKSNDIFKNR
VSAHHSSKGKGGGNYDVKDIVEYPGKEDLAIVHVHETSTEGLNFNKNVSY
TKFADGAKVKDRISVIGYPKGAQTKYKMFESTGTINHISGTFMEFDAYAQ
PGNSGSPVLNSKHELIGILYAGSGDESEKNFGVYFTPQLKEFIQNNIEK
3D structure
PDB3ufa Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VPF A H39 A149 Q150 P151 G152 S154 L169 A171 N181 H39 A149 Q150 P151 G152 S154 L169 A171 N180 PDBbind-CN: -logKd/Ki=5.00,Ki=10uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ufa, PDBe:3ufa, PDBj:3ufa
PDBsum3ufa
PubMed24375505
UniProtQ2FXC2|SPLA_STAA8 Serine protease SplA (Gene Name=splA)

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