Structure of PDB 3uby Chain A

Receptor sequence
>3ubyA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
GPHMTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLG
PEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACV
LLRALEPLEGLETMRQLRSTLLKDRELCSGPSKLCQALAINKSFDQRDLA
QDEAVWLERGPLEPSEPAVVAAARVGVAGEWARKPLRFYVRGSPWVSVVD
RVAE
3D structure
PDB3uby Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y127 H136 M149 Y159 I161 Y162 Y165 C167 N169 L180 R197 G217 P218 S219 K220 V262 G263 Y48 H57 M70 Y80 I82 Y83 Y86 C88 N90 L101 R118 G130 P131 S132 K133 V175 G176 PDBbind-CN: Kd=21nM
BS02 dna A R141 T143 P144 R145 Y162 G163 R62 T64 P65 R66 Y83 G84 PDBbind-CN: Kd=21nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3uby, PDBe:3uby, PDBj:3uby
PDBsum3uby
PubMed22148158
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

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