Structure of PDB 3ubh Chain A

Receptor sequence

>3ubhA (length=409) Species: 7227 (Drosophila melanogaster)

RAVRPTKRIEFTEADGDTEGKSVFQLEKETDKETFKIRDDNPWVTVETNG
AVRVKKKWDYEELGPEKTIDFWVIITNHNAGIKYTDNQRVIILVKDVNDE
PPYFINRPLPMQAVVQLNAPPNTPVFTLQARDPDTDHNIHYFIVRDRTGG
RFEVDERSGVVRTRGTDLFQLDMEYVLYVKAEDQNGKVRRFQSTPEERLS
IVGGKRAPQFYMPSYEAEIPENQKKDSDIISIKAKSFADREIRYTLKAQG
QGAGTFNIGPTSGIVKLAKELDFEDLRQPHVYSLIVTATEDSGGFSTSVD
LTIRVTDVNDNAPKFELPDYQAHNVDEDIPLGTSILRVKAMDSDSGSNAE
IEYLVSDDHFAVDSNGIIVNNKQLDADNNNAYYEFIVTAKDKGEPPKSGV
ATVRVYTKN

3D structure

• PDB: 3ubh Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers.
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E450 D496 E498 D538 E539	E13 D59 E61 D99 E100
BS02	CA	A	E450 E498 D535 V536 D538 D573	E13 E61 D96 V97 D99 D134
BS03	CA	A	N537 E539 D571 D573 D622 Q633	N98 E100 D132 D134 D183 Q192
BS04	CA	A	E662 D713 E715 D751	E221 D272 E274 D310
BS05	CA	A	E662 E715 D748 V749 D751 D785	E221 E274 D307 V308 D310 D344
BS06	CA	A	N750 N752 D783 D785 N789 D832	N309 N311 D342 D344 N348 D391

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:3ubh, PDBe:3ubh, PDBj:3ubh
• PDBsum: 3ubh
• PubMed: 22171007
• UniProt: O15943|CADN_DROME Neural-cadherin (Gene Name=CadN)