Structure of PDB 3uag Chain A

Receptor sequence
>3uagA (length=430) Species: 562 (Escherichia coli) [Search protein sequence]
ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV
ERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCR
EAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE
CELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLR
IYENAKVCVVNADDALTMPIERCVSFGVNMGDYHLNHETWLRVKGEKVLN
VKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVL
EHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLAR
YLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMV
LLSPACASLDQFKNFEQRGNEFARLAKELG
3D structure
PDB3uag Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.
ChainA
Resolution1.77 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K115 S116 N138 L147 H183
Catalytic site (residue number reindexed from 1) K115 S116 N138 L147 H183
Enzyme Commision number 6.3.2.9: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMA A G14 L15 T16 D35 T36 R37 P72 G73 G137 N138 G140 F161 H183 G14 L15 T16 D35 T36 R37 P72 G73 G137 N138 G140 F161 H183
BS02 ADP A N113 G114 K115 S116 T117 H267 N271 R302 D317 K319 A320 S325 A328 N113 G114 K115 S116 T117 H260 N264 R295 D310 K312 A313 S318 A321
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3uag, PDBe:3uag, PDBj:3uag
PDBsum3uag
PubMed10356330
UniProtP14900|MURD_ECOLI UDP-N-acetylmuramoylalanine--D-glutamate ligase (Gene Name=murD)

[Back to BioLiP]