Structure of PDB 3ua9 Chain A

Receptor sequence
>3ua9A (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSAAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLIT
YQIMRPE
3D structure
PDB3ua9 Structural basis of selective inhibition of human tankyrases.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 H1084 C1089 C1092 C130 H133 C138 C141
BS02 IWR A F1035 A1038 G1043 F1044 D1045 H1048 Y1050 Y1060 Y1071 F84 A87 G92 F93 D94 H97 Y99 Y109 Y120 PDBbind-CN: -logKd/Ki=7.25,IC50=56nM
BindingDB: IC50=135nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3ua9, PDBe:3ua9, PDBj:3ua9
PDBsum3ua9
PubMed22233320
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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