Structure of PDB 3ua8 Chain A

Receptor sequence
>3ua8A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT
IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK
PFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAV
FDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK
PCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKW
WYDKGEC
3D structure
PDB3ua8 6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 08W A E13 Y61 P89 L90 T91 R96 T174 E193 M196 E9 Y57 P85 L86 T87 R92 T170 E189 M192 MOAD: ic50=14nM
PDBbind-CN: -logKd/Ki=7.85,IC50=14nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3ua8, PDBe:3ua8, PDBj:3ua8
PDBsum3ua8
PubMed22197388
UniProtP42262|GRIA2_HUMAN Glutamate receptor 2 (Gene Name=GRIA2)

[Back to BioLiP]