Structure of PDB 3u7k Chain A

Receptor sequence
>3u7kA (length=185) Species: 93062 (Staphylococcus aureus subsp. aureus COL) [Search protein sequence]
MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIA
KRYGLRSGVGLAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSV
QEAYLPTGEGCLSVDDNVAGLVHRHNRITIKAKDIEGNDIQLRLKGYPAI
VFQHEIDHLNGVMFYDHIDKDHPLQPHTDAVEVLE
3D structure
PDB3u7k Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G60 Q65 C111 L112 H154 E155 H158
Catalytic site (residue number reindexed from 1) G60 Q65 C111 L112 H154 E155 H158
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MDB A Q45 R56 S57 G58 V59 G60 Q65 E109 G110 A111 L112 H154 E155 H158 Q45 R56 S57 G58 V59 G60 Q65 E109 G110 A111 L112 H154 E155 H158 PDBbind-CN: -logKd/Ki=7.07,Ki=84.9nM
BS02 ZN A A111 H154 H158 A111 H154 H158
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0018206 peptidyl-methionine modification

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Molecular Function
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Biological Process
External links
PDB RCSB:3u7k, PDBe:3u7k, PDBj:3u7k
PDBsum3u7k
PubMed22751663
UniProtQ5HGZ3|DEF_STAAC Peptide deformylase (Gene Name=def)

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