Structure of PDB 3u7g Chain A

Receptor sequence
>3u7gA (length=377) Species: 10090 (Mus musculus) [Search protein sequence]
LGWESLKKLLVFTASGVKPQGKVAAFALDGTLITTRSGKVFPTSPSDWRI
LYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLG
VPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRL
ANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPR
TISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHV
NRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVP
CRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEG
FLEILEIPFRLQLDPALQRLYRQFSEG
3D structure
PDB3u7g Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D172 V183 F184 N217 Q218 M219 G220 R223 K225 R258 F305 D29 V40 F41 N74 Q75 M76 G77 R80 K82 R115 F162
BS02 MG A D172 D288 D29 D145
BS03 PO4 A L171 D172 T216 N217 K259 L28 D29 T73 N74 K116
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3u7g, PDBe:3u7g, PDBj:3u7g
PDBsum3u7g
PubMed22171004
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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