Structure of PDB 3u6i Chain A

Receptor sequence
>3u6iA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
VHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDN
DGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSE
GSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLPVKWMALESLQTQKFTTKSDVWSFG
VLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVH
3D structure
PDB3u6i Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D154 A156 R158 N159 D172
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 044 A I1084 F1089 V1092 A1108 F1124 E1127 G1128 M1131 L1157 Y1159 M1160 M1211 D1222 F1223 I34 F39 V42 A58 F74 E77 G78 M81 L107 Y109 M110 M161 D172 F173 PDBbind-CN: -logKd/Ki=9.00,Ki=1nM
BindingDB: IC50=1nM,Ki=1.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3u6i, PDBe:3u6i, PDBj:3u6i
PDBsum3u6i
PubMed22320343
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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