Structure of PDB 3u5l Chain A

Receptor sequence
>3u5lA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB3u5l Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
ChainA
Resolution1.39 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 08K A W81 P82 F83 L92 N140 I146 W40 P41 F42 L51 N99 I105 MOAD: Kd=0.64uM
PDBbind-CN: -logKd/Ki=6.19,Kd=0.64uM
BindingDB: Kd=640nM
External links
PDB RCSB:3u5l, PDBe:3u5l, PDBj:3u5l
PDBsum3u5l
PubMed22137933
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]