Structure of PDB 3u51 Chain A

Receptor sequence
>3u51A (length=256) Species: 9031 (Gallus gallus) [Search protein sequence]
EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQE
AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGFPIK
WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQY
QPGENL
3D structure
PDB3u51 Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
ChainA
Resolution2.241 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D126 R128 A130 N131 D144 F147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A C277 F278 E280 V281 A293 K295 L297 Y340 M341 S345 D386 A390 L393 F424 P425 C17 F18 E20 V21 A33 K35 L37 Y80 M81 S85 D126 A130 L133 F147 P148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3u51, PDBe:3u51, PDBj:3u51
PDBsum3u51
PubMed22344177
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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