Structure of PDB 3u4l Chain A

Receptor sequence
>3u4lA (length=353) Species: 9913 (Bos taurus) [Search protein sequence]
AALVVDNGSGMCKAGFAGDDAPRAVFPSIVGDSYVGDEAQSKRGIKYPIE
HGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQI
MFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALP
HAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALD
FEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESC
GIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAP
STMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHR
KCF
3D structure
PDB3u4l Structural basis for profilin-mediated actin nucleotide exchange.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G13 S14 G15 M16 G156 D157 K213 E214 G301 G302 T303 M305 Y306 K336 G8 S9 G10 M11 G134 D135 K191 E192 G279 G280 T281 M283 Y284 K314
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0098973 structural constituent of postsynaptic actin cytoskeleton
Biological Process
GO:0007409 axonogenesis
GO:0048870 cell motility
GO:0098974 postsynaptic actin cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030424 axon
GO:0032991 protein-containing complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0045202 synapse
GO:0097433 dense body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3u4l, PDBe:3u4l, PDBj:3u4l
PDBsum3u4l
PubMed22366544
UniProtP60712|ACTB_BOVIN Actin, cytoplasmic 1 (Gene Name=ACTB)

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