Structure of PDB 3u1r Chain A

Receptor sequence

>3u1rA (length=456) Species: 686394 (Flavobacterium sp. YS-80-122)

GTSSAFTQVDNFSHFYDRGNHLVNGKPSFTVDQAADQLTRSGASWYDLNG
DGVINLSYTFLTSPPPGYASRGLGTFSSFSGLQKEQAKLSLESWADVAKV
TFTEGPAARGDDGHMTFANFSASNGGAAFAYLPNSSRKGESWYLINKDYD
VNKTPGEGNYGRQTLTHEIGHTLGLSHPGDYNPSYRDAVYGEDTRAYSVM
SYWSEKNTGQVFTKTGEGAYASAPLLDDIAAVQKLYGANMETRAGDTVYG
FNSTADRDYYSATSATDKLIFSVWDGGGNDTLDFSGFSQNQKINLAAGSF
SDVGGMTGNVSIAQGVTIENAIGGSGNDLLLGNAASNILKGGAGNDIIYG
GGGADKLWGGSGSDTFVYREVSDSTPKAADTLMDFQTGLDKIDLTGITHL
SGLNFVNAFTGQAGDAVVSYNQASNAGSLQVDFSGHGVADFLITTVGQVA
TYDIVA

3D structure

• PDB: 3u1r Structure analysis of a new psychrophilic marine protease.
• Chain: A
• Resolution: 2.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H186 H190 H196 Y226	H167 H171 H177 Y202
BS02	CA	A	D66 N68 D70 V72 N74 D131	D47 N49 D51 V53 N55 D112
BS03	CA	A	R267 G269 T271 D299 G301 D304	R243 G245 T247 D275 G277 D280
BS04	CA	A	G302 D304 T341 E343	G278 D280 T317 E319
BS05	CA	A	G348 G350 D352 G365 A367 D370	G324 G326 D328 G341 A343 D346
BS06	CA	A	G366 A367 G368 D370 G383 G384 S385 D388	G342 A343 G344 D346 G359 G360 S361 D364
BS07	CA	A	N357 A359 N361 G374 G376 D379	N333 A335 N337 G350 G352 D355
BS08	CA	A	G375 G376 G377 D379 D397 D404	G351 G352 G353 D355 D373 D380
BS09	CA	A	G384 G386 D388 Q410 D414	G360 G362 D364 Q386 D390

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005509 calcium ion binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0031012 extracellular matrix

External links

• PDB: RCSB:3u1r, PDBe:3u1r, PDBj:3u1r
• PDBsum: 3u1r
• PubMed: 22132082
• UniProt: D0VMS8