Structure of PDB 3u11 Chain A

Receptor sequence
>3u11A (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
DSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESIL
GELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGD
YIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRT
ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKN
3D structure
PDB3u11 Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A V642 T650 F658 G659 E660 I661 C662 R669 T670 R710 V122 T130 F138 G139 E140 I141 C142 R149 T150 R190 Manual survey: Kd=39.2nM (22006928)
External links
PDB RCSB:3u11, PDBe:3u11, PDBj:3u11
PDBsum3u11
PubMed22006928
UniProtQ9Y3Q4|HCN4_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Gene Name=HCN4)

[Back to BioLiP]