Structure of PDB 3u10 Chain A

Receptor sequence
>3u10A (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
DSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSIL
GELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGD
YIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRT
ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSI
LL
3D structure
PDB3u10 Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A V591 M599 F607 G608 E609 I610 C611 R618 T619 A620 R659 I663 V122 M130 F138 G139 E140 I141 C142 R149 T150 A151 R190 I194 Manual survey: Kd=82.0nM (22006928)
PDBbind-CN: -logKd/Ki=5.44,Kd=3.6uM
External links
PDB RCSB:3u10, PDBe:3u10, PDBj:3u10
PDBsum3u10
PubMed22006928
UniProtQ9UL51|HCN2_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Gene Name=HCN2)

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