Structure of PDB 3u0z Chain A

Receptor sequence
>3u0zA (length=199) Species: 10090 (Mus musculus) [Search protein sequence]
DSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENIL
SELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGD
YIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRT
ASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNS
3D structure
PDB3u0z Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A L521 F527 G528 E529 I530 C531 R538 T539 R579 R582 L132 F138 G139 E140 I141 C142 R149 T150 R190 R193 Manual survey: Kd=39.7nM (22006928)
External links
PDB RCSB:3u0z, PDBe:3u0z, PDBj:3u0z
PDBsum3u0z
PubMed22006928
UniProtO88704|HCN1_MOUSE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Gene Name=Hcn1)

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