Structure of PDB 3tzz Chain A

Receptor sequence
>3tzzA (length=463) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
LPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAELAD
WMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGK
QAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDA
LVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKPAA
VIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMA
LVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEG
KFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYI
KPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQ
VALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFS
RASGPQDYANIPP
3D structure
PDB3tzz Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
ChainA
Resolution2.49 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S801 L802 R826 H909 G962
Catalytic site (residue number reindexed from 1) S205 L206 R230 H313 G366
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XPM A F719 S801 L802 R826 M830 G833 E834 L837 G906 S908 H909 Q912 M913 F123 S205 L206 R230 M234 G237 E238 L241 G310 S312 H313 Q316 M317
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:3tzz, PDBe:3tzz, PDBj:3tzz
PDBsum3tzz
PubMed22825853
UniProtO53579

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