Structure of PDB 3tzy Chain A

Receptor sequence
>3tzyA (length=464) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
ELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAELA
DWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAG
KQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVD
ALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKPA
AVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLM
ALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAE
GKFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRY
IKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALM
QVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLF
SRASGPQDYANIPP
3D structure
PDB3tzy Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S801 L802 R826 H909 G962
Catalytic site (residue number reindexed from 1) S206 L207 R231 H314 G367
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L624 L678 P699 N700 F702 M995 P1013 Q1019 S1027 Q1031 L29 L83 P104 N105 F107 M400 P418 Q424 S432 Q436
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:3tzy, PDBe:3tzy, PDBj:3tzy
PDBsum3tzy
PubMed22825853
UniProtO53579

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