Structure of PDB 3tzx Chain A

Receptor sequence
>3tzxA (length=465) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAEL
ADWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAA
GKQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKV
DALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKP
AAVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRL
MALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEA
EGKFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGR
YIKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVAL
MQVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTL
FSRASGPQDYANIPP
3D structure
PDB3tzx Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S801 L802 R826 H909 G962
Catalytic site (residue number reindexed from 1) S207 L208 R232 H315 G368
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L624 L678 H680 P699 N700 F702 P1013 Q1019 S1027 L30 L84 H86 P105 N106 F108 P419 Q425 S433
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:3tzx, PDBe:3tzx, PDBj:3tzx
PDBsum3tzx
PubMed22825853
UniProtO53579

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