Structure of PDB 3tzw Chain A

Receptor sequence
>3tzwA (length=467) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
ELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAELA
DWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAG
KQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVD
ALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKPA
AVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLM
ALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAE
GKFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRY
IKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALM
QVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLF
SRASGPQDYANIPPTRF
3D structure
PDB3tzw Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S801 L802 R826 H909 G962
Catalytic site (residue number reindexed from 1) S206 L207 R231 H314 G367
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H680 P699 N700 F702 P1013 S1027 Q1031 H85 P104 N105 F107 P418 S432 Q436
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:3tzw, PDBe:3tzw, PDBj:3tzw
PDBsum3tzw
PubMed22825853
UniProtO53579

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