Structure of PDB 3tyk Chain A

Receptor sequence
>3tykA (length=296) Species: 562 (Escherichia coli) [Search protein sequence]
TATSVEKFLIEKFDSVSDLMQLSEGEESRAFSFDVGGRGYVLRVNSCADG
FYKDRYVYRHFASAALPIPEVLDIGEFSESLTYCISRRAQGVTLQDLPET
ELPAVLQPVAEAMDAIAAADLSQTSGFGPFGPQGIGQYTTWRDFICAIAD
PHVYHWQTVMDDTVSASVAQALDELMLWAEDCPEVRHLVHADFGSNNVLT
DNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLACMEQQTRYFERRHPEL
AGSPRLRAYMLRIGLDQLYQSLVDGNFDDAAWAQGRCDAIVRSGAG
3D structure
PDB3tyk Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.163: hygromycin B 4-O-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HY0 A Q101 D198 S201 N231 W235 W238 L239 D285 Q95 D192 S195 N225 W229 W232 L233 D279
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:3tyk, PDBe:3tyk, PDBj:3tyk
PDBsum3tyk
PubMed21084294
UniProtP00557|KHYB_ECOLX Hygromycin-B 4-O-kinase (Gene Name=hph)

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