Structure of PDB 3twx Chain A

Receptor sequence
>3twxA (length=158) Species: 9606 (Homo sapiens) [Search protein sequence]
MGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY
NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN
VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD
TDIQDLLR
3D structure
PDB3twx Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R525 S527 F532 G535 Y536 L560 N565 S568 Y569 H571 D589 W591 F593 E598 R39 S41 F46 G49 Y50 L74 N79 S82 Y83 H85 D103 W105 F107 E112
BS02 peptide A N537 V539 E573 N51 V53 E87
External links
PDB RCSB:3twx, PDBe:3twx, PDBj:3twx
PDBsum3twx
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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