Structure of PDB 3tww Chain A

Receptor sequence
>3twwA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
3D structure
PDB3tww Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R525 S527 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 R38 S40 G48 Y49 L73 N78 Y82 H84 D102 W104 F106 E111
BS02 peptide A N537 V539 E573 N50 V52 E86
External links
PDB RCSB:3tww, PDBe:3tww, PDBj:3tww
PDBsum3tww
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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