Structure of PDB 3twu Chain A

Receptor sequence
>3twuA (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR
VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA
DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD
IQDLLRGDAA
3D structure
PDB3twu Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R525 F532 G535 Y536 N537 L560 N565 S568 Y569 H571 D589 W591 F593 E598 K604 R37 F44 G47 Y48 N49 L72 N77 S80 Y81 H83 D101 W103 F105 E110 K116
External links
PDB RCSB:3twu, PDBe:3twu, PDBj:3twu
PDBsum3twu
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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