Structure of PDB 3tws Chain A

Receptor sequence
>3twsA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV
SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD
LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI
QDLLRGD
3D structure
PDB3tws Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 D624 R36 S38 F43 G46 Y47 L71 N76 Y80 H82 D100 W102 F104 E109 D135
BS02 peptide A N537 V539 E543 E573 N48 V50 E54 E84
External links
PDB RCSB:3tws, PDBe:3tws, PDBj:3tws
PDBsum3tws
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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