Structure of PDB 3tvl Chain A

Receptor sequence
>3tvlA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
GLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHW
LRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGA
GDVAAVLGPLGLQEVASFVTKRSAWKLVLPQLRVDLDTADFGYAVGEVEA
LVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLL
EVNS
3D structure
PDB3tvl Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.28: thiamine-triphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3PO A K11 R55 R57 K65 R125 K8 R52 R54 K62 R122 PDBbind-CN: -logKd/Ki=4.00,Kd<0.1mM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0050333 thiamine triphosphate phosphatase activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006772 thiamine metabolic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0016311 dephosphorylation
GO:0042357 thiamine diphosphate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3tvl, PDBe:3tvl, PDBj:3tvl
PDBsum3tvl
PubMed23707715
UniProtQ9BU02|THTPA_HUMAN Thiamine-triphosphatase (Gene Name=THTPA)

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