Structure of PDB 3tub Chain A

Receptor sequence
>3tubA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDP
ALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ
QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKIS
DFGLPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE
VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY
YDV
3D structure
PDB3tub Identification of Type-II Inhibitors Using Kinase Structures.
ChainA
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512
Catalytic site (residue number reindexed from 1) D133 A135 R137 N138 D151
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FPU A L377 A400 E420 M424 L427 M448 A451 S511 D512 F513 L16 A39 E59 M63 L66 M87 A90 S150 D151 F152 MOAD: ic50=320nM
BindingDB: IC50=320nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3tub, PDBe:3tub, PDBj:3tub
PDBsum3tub
PubMed22759374
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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