Structure of PDB 3tu1 Chain A

Receptor sequence
>3tu1A (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB3tu1 Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists.
ChainA
Resolution1.603 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 07G A L54 G58 I61 M62 V93 H96 I99 L37 G41 I44 M45 V76 H79 I82 MOAD: Ki=0.25uM
PDBbind-CN: -logKd/Ki=6.60,Ki=0.25uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3tu1, PDBe:3tu1, PDBj:3tu1
PDBsum3tu1
PubMed21954050
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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