Structure of PDB 3tsb Chain A

Receptor sequence
>3tsbA (length=490) Species: 198094 (Bacillus anthracis str. Ames) [Search protein sequence]
QSNAMWESKFVKEGLTFDDVLLVPAKSDVLPREVSVKTVLSESLQLNIPL
ISAGMDTVTEADMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSESGVI
SDPFFLTPEHQVYDAEHLMGKYRISGVPVVNNLDERKLVGIITNRDMRFI
QDYSIKISDVMTKEQLITAPVGTTLSEAEKILQKYKIEKLPLVDNNGVLQ
GLITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADAMTRIDALVKASVD
AIVLDTAHGHSQGVIDKVKEVRAKYPSLNIIAGNVATAEATKALIEAGAN
VVKVGIGPGSICTTRVVAGVGVPQLTAVYDCATEARKHGIPVIADGGIKY
SGDMVKALAAGAHVVMLGSMFAGVAESPGETEIYQGRQFKVYRGMGSVGA
MEKGSKDRYFQEGNKKLVPEGIEGRVPYKGPLADTVHQLVGGLRAGMGYC
GAQDLEFLRENAQFIRMSGAGLLESHPHHVQITKEAPNYS
3D structure
PDB3tsb Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.
ChainA
Resolution2.595 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A G305 S306 G343 G364 S365 Y388 G309 S310 G347 G368 S369 Y392
BS02 PO4 A R119 K206 R123 K210
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3tsb, PDBe:3tsb, PDBj:3tsb
PDBsum3tsb
PubMed22788966
UniProtA0A6L8P2U9

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