Structure of PDB 3ts2 Chain A

Receptor sequence

>3ts2A (length=135) Species: 10090 (Mus musculus)

QLLHGAGICKWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEGFR
SLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGSERRPKGGDRCYNCGG
LDHHAKECKLPPQPKKCHFCQSINHMVASCPLKAQ

3D structure

• PDB: 3ts2 Molecular Basis for Interaction of let-7 MicroRNAs with Lin28.
• Chain: A
• Resolution: 2.01 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	W46 N48 V49 R50 M51 F53 F55 D71 F73 H75 Q76 G83 F84 R85 S100 K102 E105 R122 R123	W11 N13 V14 R15 M16 F18 F20 D36 F38 H40 Q41 G48 F49 R50 S65 K67 E70 R87 R88
BS02	rna	A	D137 R138 C139 Y140 H148 A149 K159 K160 C161 H162 M170 V171 K177	D93 R94 C95 Y96 H104 A105 K115 K116 C117 H118 M126 V127 K133
BS03	ZN	A	C139 C142 H147 C152	C95 C98 H103 C108
BS04	ZN	A	C161 C164 H169 C174	C117 C120 H125 C130

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

External links

• PDB: RCSB:3ts2, PDBe:3ts2, PDBj:3ts2
• PDBsum: 3ts2
• PubMed: 22078496
• UniProt: Q8K3Y3|LN28A_MOUSE Protein lin-28 homolog A (Gene Name=Lin28a)